[HTML][HTML] The effects of TGF-β1 and IGF-I on the biomechanics and cytoskeleton of single chondrocytes
OBJECTIVE: Ascertaining how mechanical forces and growth factors mediate normal and
pathologic processes in single chondrocytes can aid in developing strategies for the repair
and replacement of articular cartilage destroyed by injury or disease. This study examined
effects of transforming growth factor-β1 (TGF-β1) and insulin-like growth factor-I (IGF-I) on
the biomechanics and cytoskeleton of single zonal chondrocytes. METHOD: Superficial and
middle/deep bovine articular chondrocytes were seeded on tissue culture treated plastic for …
pathologic processes in single chondrocytes can aid in developing strategies for the repair
and replacement of articular cartilage destroyed by injury or disease. This study examined
effects of transforming growth factor-β1 (TGF-β1) and insulin-like growth factor-I (IGF-I) on
the biomechanics and cytoskeleton of single zonal chondrocytes. METHOD: Superficial and
middle/deep bovine articular chondrocytes were seeded on tissue culture treated plastic for …
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